肠道微生物群调节脂肪性eicosanoid代谢:氧化酶途径的潜在作用
Yige Wang1, Matthew L Edin2, Nan Jing1
1Department of Nutrition, University of California, Davis, Davis, California, USA.
概括
肠道微生物影响脂肪组织功能和代谢疾病. 这项研究揭示了肠道微生物群改变来自5-和12/15-氧基酶 (LOX) 的特定脂质介质 (LMs),影响脂肪平衡.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肠道微生物群研究研究
- 脂质介质的信号传递方式
背景情况:
- 肠道微生物群显著影响脂肪组织功能和炎症,影响肥胖和糖尿病.
- 之前的研究集中在蛋白质介质上,不清楚脂质介质 (LMs) 在微生物群-脂肪相互作用中的作用.
- 脂质介质对于维持脂肪组织平衡至关重要.
研究的目的:
- 研究脂质媒介在肠道微生物群与脂肪组织相互作用中的作用.
- 为了比较无菌和传统养小鼠之间的脂肪组织中的LM概况.
- 阐明肠道微生物群影响脂肪功能的新机制.
主要方法:
- 利用基于高性能液体染色学-并联质谱学 (LC-MS/MS) 的向脂质组学来量化超过100个LM.
- 从无细菌 (GF) 和无特定病原体 (SPF) 的小鼠的脂肪组织中比较了LM档案.
- 在脂肪组织中分析了脂氧酶 (LOX) 的转录表达.
主要成果:
- 与GF对照组相比,在传统养的小鼠中观察到由5-和12/15-脂氧酶 (LOX) 衍生的LMS的显著变化.
- 发现肠道微生物群可以降低脂肪组织中5-和12/15-LOX的表达.
- 在传统养小鼠中,5-和12/15-LOX衍生代谢物的循环水平降低了.
结论:
- 肠道微生物群调节脂肪功能,并可能通过LOX衍生的脂质介质的改变影响代谢疾病的发展.
- 这些发现表明,一种新的机制涉及肠道微生物群对5-和12/15-LOX通路的下调.
- 脂肪组织中的脂质介质概况受到肠道微生物群的存在的显著影响.
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