南非中年成年人中的药物类别重复模式:来自药物索赔数据库的发现
Danielle Hope Fourie1, Johanita Riétte Burger2, Jesslee Melinda du Plessis1
1Medicine Usage in South Africa (MUSA), North-West University, Potchefstroom, South Africa.
International journal of clinical pharmacy
|February 24, 2026
概括
药物类重复,即处方同一类的两种药物,影响了近一半的中年成年人. 这一常见问题,特别是在他类药物和NSAIDs方面,突显了改善患者安全的干预措施的必要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 老年医学 老年医学
背景情况:
- 中年成年人 (45-64岁) 面临可能不合适的药物 (PIM) 处方的风险,因为多病症.
- 药物类重复,一个常见的PIM,涉及同一药理类的同时处方.
研究的目的:
- 为了确定中年成年人中药类重复的流行率.
- 为了按性别和年龄组分层流行率.
- 使用南非药物索赔数据,识别与药物类重复相关的因素.
主要方法:
- 一项横截面研究分析了2023年1月1日至12月31日的药物索赔数据.
- 在14个药理学类别中评估了药物类别重复性.
- 流行率根据性别和年龄进行了分析,使用千平方和斯皮尔曼相关性测试了相关性.
主要成果:
- 在195,446名被分析的患者中,近一半 (48.8%) 经历了药物类重复.
- 双重发生在性别之间是相似的,但在老年人群中较高 (p < 0.0001).
- 最常见的重复包括他类药物 (18.9%),NSAIDs (15.8%),ACE抑制剂 (13.1%),和ARBs (11.5%).
- 在重复和慢性疾病的数量 (rs=0.680) 和处方 (rs=0.638) 之间发现了强烈的相关性.
结论:
- 药物类别重复是中年成年人普遍存在的问题.
- 较高的重复率与增加的多病症和多药性相关.
- 建议采取有针对性的干预措施,以提高患者的安全性.
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