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Updated: Feb 26, 2026

Reliably Engineering and Controlling Stable Optogenetic Gene Circuits in Mammalian Cells
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合成基因电路可以选择性地准RAS驱动的癌症

Gabriel Valentin Senn1, Leon Nissen1, Yaakov Benenson1

  • 1Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

eLife
|February 24, 2026
PubMed
概括

合成基因电路精确地准癌细胞中的突变大鼠肉瘤 (RAS) 瘤基因. 这种新的方法提高了选择性和治疗性蛋白质表达,以改善癌症治疗.

关键词:
在 RAS 传感器上.生物化学 生物化学癌症生物学 癌症生物学针对癌症的向蛋白质表达.化学生物学 化学生物学人类 人类 人类 人类 人类 人类 人类多输入逻辑电路的多输入逻辑电路.鼠类肉瘤是一种基因癌症.合成生物学 合成生物学合成的基因电路.

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