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Updated: Feb 26, 2026

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在共同培养过程中,食源可以改变病原体的抗生素耐药性吗?

Alexander D H Kingdon^1,2, Elena Jordana-Lluch^1,3, Kim Rachael Hardie¹

¹Biodiscovery Institute and National Biofilms Innovation Centre, School of Life Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.

Journal of medical microbiology

|February 24, 2026

概括

与Pseudomonas aeruginosa和Staphylococcus aureus等伤口病原体共同培养细菌,包括开始性细菌,降低了抗生素耐药性. 这表明微生物群落会影响治疗的有效性.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
抗微生物耐药性抗微生物耐药性

背景情况:

细菌性伤口感染,特别是在烧伤和糖尿病足中,会延长住院时间,并加重患者的结果.
关键的病原体包括Pseudomonas aeruginosa和Staphylococcus aureus,但像Staphylococcus epidermidis和Micrococcus luteus这样的共生细菌也存在.
同时感染对单个细菌物种抗生素耐药性概况的影响在很大程度上仍未被描述.

研究的目的:

研究双种共同培养 (共生病原体) 对每个细菌物种抗生素耐药性的影响.
评估共同培养环境中的物种间相互作用如何影响抗菌素易感性.

主要方法:

开始性和致病性细菌物种被单独培养和在双种共同培养中培养,在24小时内可能形成生物膜.
随后,培养物被用抗生素 (西普罗夫洛克萨或托布拉米) 治疗.
使用最小生物膜消灭度 (MBEC) 和细菌活力计数来比较单个物种和共同培养条件之间的抗生素耐药性.

主要成果:

当物种与单一物种培养相比,共同培养时,细菌生存能力降低.
共同培养导致抗生素耐药性降低,特别是在Pseudomonas aeruginosa (较低的MBEC) 中.
其他物种的抗生素耐药性受到特定的物种间作用的影响.

结论:

与病原体共同培养的共生细菌的存在可以降低抗生素耐药性.
微生物群落内的物种间相互作用显著影响病原体的生存能力.
抗生素耐药性评估协议应考虑微生物社区的动态,以便更有效地治疗伤口感染.

关键词:

微型白球菌 (Micrococcus luteus) 是一种微型白球菌.伪omonas aeruginosa 这种类型的病毒.这种病原体是葡萄球菌.抗生素耐药性抗生素耐药性聚微生物生物膜是一种多微生物生物膜.

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