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Updated: Feb 26, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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药物诱导的高 bilirubinemia 的风险评估:一个机械的方法

Rajeev Kumar1, Ansu Kumar1, Aftab Alam1

  • 1Cellworks Group, Inc., South San Francisco, California, USA.

CPT: pharmacometrics & systems pharmacology
|February 24, 2026
PubMed
概括

这项研究开发了一种机械模型,使用遗传标记和药物相互作用数据来预测药物诱导的高白血病风险. 该模型有助于根据遗传变异和药物对肝脏载体和酶的影响来评估患者的风险.

关键词:
在MRP2中,MRP2是MRP2.在MRP3中,MRP3是MRP3.这是一个OATP1B1B1的OATP.美国UGT1A1过高bilirubinemia 这种疾病.

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