延长大麻戒断对并发性创伤后应激障碍和大麻使用障碍的影响
Justyne D Rodas1,2,3, Maryam Sorkhou1,2,3, Stefan Kloiber2,4,5,6
1Institute for Mental Health and Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
The Journal of clinical psychiatry
|February 24, 2026
概括
在患有并发性PTSD和大麻使用障碍 (CUD) 的个体中,达到12周的禁用大麻显著减少了创伤后应激障碍 (PTSD) 症状. 持续使用大麻可能会阻碍康复,强调需要综合治疗方法.
科学领域:
- 精神病学是一个精神病学.
- 成 药物 药物 药物 药物
- 临床心理学 临床心理学
背景情况:
- 创伤后应激障碍 (PTSD) 和大麻使用障碍 (CUD) 的并发症很普遍.
- 持续戒毒对伴并发性CUD患者PTSD症状的影响仍未得到充分研究.
研究的目的:
- 检查12周大麻戒断与患有并发性PTSD和CUD的个体中PTSD症状的改善之间的关联.
主要方法:
- 一项初步的开放性研究,涉及21名患有PTSD和CUD的参与者.
- 参与者通过THC-COOH水平和自我报告来验证,获得了实现戒断的强化.
- 使用DSM-5 (CAPS-5) 的临床医生管理的PTSD尺度评估了PTSD症状.
主要成果:
- 与非戒断者 (n=10) 相比,实现戒断的个人 (n=11) 在总PTSD症状严重程度和症状数量上显著减少.
- 禁酒者在避免,负面情绪/认知和过度兴奋症状方面经历了更明显的改善.
- 在这两组中,再次经历症状的情况都有所改善,根据戒断状态没有显著差异.
结论:
- 持续12周的大麻戒断与PTSD症状严重程度和频率的显著减少有关.
- 这些发现挑战了长期使用大麻有助于PTSD症状管理的观点,并表明它可能会阻碍恢复.
- 在PTSD治疗中,对大麻使用的常规评估和对潜在后果的患者教育至关重要.
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