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代谢失调:它在糖尿病和癌症中的作用

Shuang Dai¹, Jiacheng Li², Jing Xia³

¹Health and Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China; Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Molecular aspects of medicine

|February 24, 2026

概括

糖尿病通过破坏新陈代谢增加癌症风险. 未来的研究应该使用空间分析来了解糖尿病代谢物如何影响瘤微环境 (TME),以获得更好的癌症疗法.

科学领域:

在瘤学瘤学.
代谢疾病代谢疾病
癌症生物学癌症生物学

背景情况:

糖尿病是众所周知的几种癌症的风险因素,包括肝癌,胰腺癌和子宫内膜癌.
在DM中,核心代谢障碍,如高胰岛素血症,高血糖症和炎症,都与癌症的发展有关.
了解DM病理生理学和癌症生物学之间的分子联系对于开发有效的治疗策略至关重要.

研究的目的:

审查糖尿病病理生理学与癌症生物学之间的联系.
为了合成DM中的代谢干扰如何促进瘤发生.
确定挑战,并提出未来的研究方向,用于在癌症治疗中重新利用抗糖尿病药物.

主要方法:

文献综述综合了DM和癌症的当前知识.
分析DM中的代谢失调如何影响瘤性途径.
关于分子整合剂在瘤细胞中调解代谢压力的讨论.
为未来的研究整合空间分析和奥米克技术的建议.

主要成果:

在DM中的代谢障碍 (高胰岛素血症,高血糖,炎症) 失调瘤性途径 (IGF-1,DNA修复,免疫代谢).
关键的分子整合剂 (p38 MAPK,Wnt/β-catenin,AGE-RAGE) 调解代谢压力,促进瘤细胞的增殖和侵入.
这些发现的翻译应用,包括药物重新定位,由于不一致的临床结果而面临挑战.

结论:

需要一个范式的转变,超越路径分析,对瘤微环境 (TME) 的空间分析.
整合单细胞和空间奥米克可以绘制出糖尿病代谢物如何影响瘤内的特定细胞.
这种方法对于制定有针对性的策略来缓解癌症风险和改善DM和癌症患者的治疗结果至关重要.

关键词:

癌症癌症癌症癌症糖尿病是一种糖尿病.免疫代谢过程中的免疫代谢.代谢失调是代谢失调的原因之一.瘤微环境是一个微环境.

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