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评估中风后的结构连接性破坏:个体通道图还是使用基于模型的方法?

Franziska E Hildesheim¹, Keith W Jamison², Ilana R Leppert³

¹Lady Davis Institute for Medical Research, Montréal, QC, Canada; Department of Neurology & Neurosurgery, McGill University, Montréal, QC, Canada; Canadian Platform for Trials in Non-Invasive Brain Stimulation (CanStim), Montréal, QC, Canada.

NeuroImage. Clinical

|February 24, 2026

概括

缺血性中风后的结构性连接性障碍 (SCD) 可以使用单个通道图或基于模型的工具 (如NeMo.Mo) 来评估. 这两种方法都捕获了SCD模式,但出现了差异,特别是在老年人中,建议针对患者和年龄特定需求量身定制的方法.

科学领域:

神经成像是一种神经成像.
神经科学是一个神经科学.
医疗成像医学成像

背景情况:

缺血性中风显著破坏大脑的结构连接,影响功能结果.
基于扩散磁力共振成像 (MRI) 的通道图对于评估白质损伤和指导中风康复至关重要.
目前对结构连接性破坏 (SCD) 的理解,对个体曲谱和基于规范模型的估计进行比较仍然有限.

研究的目的:

为了比较结构连接中断 (SCD) 估计,从个体曲谱学与基于模型的方法 (NeMo) 来得出的估计.
评估这些方法在亚急性缺血性中风患者和不同年龄组的健康成年人中的性能.

主要方法:

分析了23名中风患者和60名健康成年人 (HCP,ADNI3队列) 的扩散MRI数据.
实验1:在中风患者中,与NeMo得分对比SCD估计的个体通道图.
实验2:将合成病变应用于健康成年人的数据,以将基于轨道图的SCD与NeMo估计进行比较.

主要成果:

在中风患者的个人通道图和NeMo SCD得分之间存在强烈的相关性 (R2 ≥0.81).
与个人通道图相比,NeMo在健康对照组中低估了SCD,在老年人中差异更大.
观察到SCD估计的区域差异,下侧状回形表现出显著的差异.

结论:

个人路径图和NeMo框架都有效地捕捉了中风后的区域性SCD模式.
在老年人中,SCD估计的差异更为明显,突出了特定于年龄的考虑因素.
尼莫框架为大型研究提供了效率,而个体曲道图可能会提供更多患者和年龄特定的见解.

关键词:

扩散权重成像技术的使用.一次性中风,中风.结构性的连接性结构性的连接性曲谱学曲谱学曲谱学曲谱学白质是白质的组成部分.

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