干眼的全球流行:系统性审查和元分析
Kunhong Xiao1, Li Li2, Xuemei Zhang3
1Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China; Department of Ophthalmology and Optometry, Fujian Medical University, Fuzhou, China.
概括
干眼症影响全球三分之一以上的人口,患病率因地区,年龄和性别而异. COVID-19 疫情似乎增加了干眼负担,突出了对标准化诊断和干预措施的需求.
科学领域:
- 眼科医生 眼科 眼科
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 干眼病 (DED) 是一种普遍影响全球生活质量和生产力的疾病.
- 现有的DED流行病学数据是分散的和过时的,限制了有效的公共卫生战略.
研究的目的:
- 为了估计干眼的全球流行情况.
- 分析不同地区,人口统计,诊断标准,研究设置和COVID-19大流行影响中DED患病率的变化.
主要方法:
- 在主要数据库 (PubMed,科学网,Embase,Cochrane图书馆) 进行了系统的文献搜索.
- 包括119个队列或横截面研究,共15251528名参与者.
- 数据被提取并独立评估质量;一个随机效应模型被用于与子组分析的聚合流行率估计.
主要成果:
- 干眼的全球综合流行率为34.6%.
- 流行率在地理位置上有所不同 (非洲最高:43.9%,北美最低:20.9%),女性,40岁以上的个人,机构设置和COVID-19大流行期间的流行率更高.
- 诊断标准显著影响了患病率估计,从6.9% (ICD-9) 到53.8% (OSDI ≥13) 之间.
结论:
- 眼睛干燥是一个重要的全球公共卫生问题,受到地理,人口,环境和方法因素的影响.
- 随着COVID-19的流行,干眼症的负担更加严重.
- 迫切需要标准化诊断协议和有针对性的干预措施,以应对眼睛干燥日益严重的影响.
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