肠道封闭的富勒重编程乳酸代谢以拯救缺氧引起的运动不耐受
Shiliang Chen1, Yiwen Pan2, Meihan Liu1
1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Biomaterials
|February 24, 2026
概括
一种新的口服富勒 (C60) 疗法针对肠道,以安全地改善慢性缺氧期间的运动耐力. 这种方法减少了肠道乳酸盐的产生,减轻了高度恶化,没有系统副作用.
科学领域:
- 生物医学科学 生物医学科学
- 生理学 生理学 生理学
- 胃肠病学 胃肠病学
背景情况:
- 慢性缺氧导致运动不耐受,这是高海拔恶化 (HADT) 的关键特征.
- 目前用于HADT的治疗方法缺乏长期的安全性和有效性.
- 针对肠道特异性机制提供了一个新的治疗途径.
研究的目的:
- 开发和评估一种口服的富勒 (C60) 悬浮剂,用于治疗慢性缺氧引起的运动不耐受症.
- 为了研究富勒在胃肠道中的作用机制.
- 为了评估富勒对HADT的安全性和有效性.
主要方法:
- 开发一种口服的富勒 (C60) 悬浮剂,其系统吸收可忽略不计.
- 给患有慢性缺氧条件的受试者服用富勒.
- 评估全身乳酸水平,运动耐力,肠道乳酸代谢,活性氧物种 (ROS) 水平,缺氧诱导因子-1α (HIF-1α) 稳定性,糖解,肠道屏障完整性和缺氧诱导的肠道损伤.
主要成果:
- 富勒显著降低了全身乳酸盐,并在慢性缺氧中增强了运动耐力.
- 富勒在肠道中局部起作用,灭肠道上皮细胞中的ROS,并破坏HIF-1α的稳定.
- 这导致了肠道糖解抑制,减少了内源性肠道乳酸盐的产生,并保持了肠道屏障的完整性.
- 没有观察到对肌肉,肝脏或脏乳酸代谢的显著影响.
结论:
- 口服富勒 (C60) 通过向肠道衍生乳酸,为HADT提供安全有效的"局部至全身"治疗策略.
- 这种方法可以减轻缺氧引起的运动不耐受性和肠道损伤,而系统暴露最小.
- 富勒烯在HADT和潜在的其他缺氧相关疾病中呈现出有前途的治疗方法.
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