较高的摄入量与认知不受损的老年男性的情节性记忆下降有关:一项长期6年研究
Francisca Chuwa1, Stephanie R Rainey-Smith2, Hilal Salim Said Al Shamsi1
1Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, 270 Joondalup Drive, Joondalup, Western Australia 6027, Australia.
Neurobiology of aging
|February 24, 2026
概括
高摄入量与男性更快的认知衰退有关,特别是在情节性回忆中. 这表明可能是大脑健康的可修改因素,这需要进一步的性别特定研究.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 新出现的证据表明,高摄入量与认知障碍之间存在联系.
- 虽然动物研究显示出明显的关系,但人类对摄入量和认知能力下降的数据不那么有说服力.
研究的目的:
- 在72个月的时间内调查自我报告的基线摄入量与认知衰退之间的关联.
- 探索潜在的性别特异性差异以及Apolipoprotein E状态对这种关系的影响.
主要方法:
- 利用了来自澳大利亚成像,生物标志物和生活方式研究的1208名认知无障碍参与者的数据 (平均年龄70.87岁,41%是男性).
- 通过食物频率问卷评估了基线摄入量,并在6年内多个时间点进行了全面的神经心理评估.
- 采用线性混合模型来分析摄入量与认知衰退之间的关联,控制混因素并按性别和Apolipoprotein E状态分层.
主要成果:
- 在男性中,摄入量和情节性回忆力下降之间发现了显著的负相关性 (FDR调整 p=0.044).
- 摄入较高的男性在情节性回忆中表现出更快的下降.
- 在整体队列,女性中,或根据Apolipoprotein E状态分层时,没有观察到任何显著的关联.
结论:
- 在男性中,较高的摄入量可能会导致加速的认知衰退,特别是情节性记忆.
- 性别特定的因素似乎在摄入量与认知功能之间的关系中起着至关重要的作用.
- 需要进一步研究性别特异性方法,以了解作为延迟认知障碍和潜在的阿尔茨海默病发病的可修改因素的作用.
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