评估经过口腔机器人手术后使用NSAID后术后出血的风险
John A Dewey1, Ryan S Ziltzer1, Meghan T Turner1
1Department of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Head & neck
|February 24, 2026
概括
术后使用非类固醇抗炎药物 (NSAID) 在过口机器人手术 (TORS) 或切除术后没有增加出血风险. 在管理TORS疼痛时,NSAID可能未被充分利用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 手术瘤学手术瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 经过口腔机器人手术 (TORS) 后使用NSAID的术后出血 (POH) 风险尚未得到充分证实.
- 关于NSAIDs在TORS患者疼痛管理中的安全性数据有限.
研究的目的:
- 为了研究术前NSAID和术后出血风险之间的关联.
- 为了评估NSAIDs在接受TORS口腔切除术的患者中的安全性.
主要方法:
- 使用TriNetX数据库进行了回顾性倾向匹配的队列研究.
- 根据TORS口腔大切除术7天内的NSAID给药,患者被分配为队列.
- 分析了1761名患者,每个倾向匹配队列中有621名患者.
主要成果:
- 整体出血率为5.5%.
- 在NSAID和非NSAID组之间,在初级POH (1.5%与1.2%),二次POH (5.2%与4.2%),30天ER呈现 (11.0%与10.6%) 或30天死亡率 (<1.5%与<0.9%) 中没有显著差异.
- 只有37.5%的患者接受了手术后的NSAID.
结论:
- 在TORS口腔切除术后使用NSAID与增加POH,ER回归或死亡率无关.
- 目前对NSAIDs用于TORS后疼痛管理的使用似乎很低.
- 进一步的研究可能支持增加NSAID用于TORS患者的疼痛控制.
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