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在转移的默克尔细胞癌中,免疫治疗后的致命结局主要原因不明

Yohan Depierre¹, Amina Faiza Chouiter-Djebaili², Hervé Zender^1,3,4

¹Service of Internal Medicine, Department of Medicine, Network Hospital Neuchâtel, La Chaux-de-Fonds, Switzerland.

BMJ case reports

|February 24, 2026

概括

默克尔细胞癌 (MCC) 是一种罕见的,激进的皮肤癌. 使用 pembrolizumab 的免疫疗法可以有效,但存在急性功能衰竭的风险,需要仔细监测患者.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
腎臟病學 (nephrology) 是一種醫學專業.

背景情况:

默克尔细胞癌 (MCC) 是一种罕见但具有高死亡率的侵袭性皮肤癌.
转移性MCC的治疗选择有限,抗编程细胞死亡蛋白1 (PD-1) 免疫疗法现在是主要策略.

研究的目的:

报告用pembrolizumab治疗的第四阶段MCC病例.
要突出与MCC患者的pembrolizumab治疗相关的急性功能衰竭的潜在风险.

主要方法:

一位患有第四期MCC的老年女性患者的病例报告.
在转移性疾病中启动 pembrolizumab 治疗.
监测不良事件,特别是脏并发症.

主要成果:

患者在第一个 pembrolizumab 输注后出现急性功能衰竭.
这一案例强调了MCC的高致病性和潜在的免疫治疗相关不良事件.

结论:

布罗利祖马布是晚期MCC的关键治疗方法,但需要对脏并发症进行警监测.
积极管理对于预测和预防在转移性MCC免疫治疗期间的不良反应至关重要.

关键词:

急性功能衰竭急性功能衰竭是什么癌症干预干预癌症干预免疫检查点抑制剂免疫检查点抑制剂皮肤癌是一种皮肤癌.

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