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在儿科炎性肠病中,肠外表现和疾病严重程度的关联:一个多中心队列研究
Ágnes Eszter Tímár1,2, Márk Hernádfői1,3, Brigitta Teutsch1,4,5
1Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
在儿科炎症性肠病 (IBD) 影响治疗中的肠外表现 (EIMs). 克罗恩病患者的EIM导致早期的生物治疗,而在性结肠炎中,它们增加了切除术的风险.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠病 (IBD) 研究研究
- 临床结果分析 临床结果分析
背景情况:
- 肠外表现 (EIM) 经常在儿科炎症性肠病 (IBD) 中观察到,并且可以显著影响患者的生活质量.
- 了解EIM在诊断和疾病严重程度之间的关联对于优化儿科IBD治疗策略至关重要.
研究的目的:
- 调查诊断时EIMs的存在与IBD儿童随后的疾病严重程度之间的关系.
- 确定EIM是否影响关键的临床结果,如复发率,类固醇依赖,需要生物治疗和手术干预.
主要方法:
- 使用来自匈牙利儿科IBD注册表 (2010-2020) 的数据进行了后期分析.
- 该研究包括诊断为克罗恩病 (CD) 或性结肠炎 (UC) 的儿科患者.
- 使用卡普兰-梅尔和考克斯回归分析来比较诊断时患有和没有EIM的患者之间的结果.
主要成果:
- 与性结肠炎 (14%) 相比,儿科克罗恩病 (25%) 中的EIM更为普遍.
- 在克罗恩氏病中,EIM与早期的类固醇依赖和生物治疗的开始有关;然而,没有EIM的患者患肠切除的风险更高.
- 在性结肠炎中,EIMs与复发或类固醇依赖性无关,但与早期的切除术有关.
结论:
- 对于儿科克罗恩病患者来说,诊断时的EIMs需要更早的生物治疗,但与更少的手术有关.
- 在儿科性结肠炎中,诊断时的EIM似乎预测了需要生物治疗和接受大肠切除术的可能性增加.
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