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Updated: Feb 26, 2026

In Vitro Assay to Study Tumor-macrophage Interaction
08:36

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

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工程巨细胞以有效和安全地准瘤微环境中的CD47癌细胞

Fernando Torres Andón1,2, Ailenis Rosales Sánchez3,2, Alba Pensado-López3,2

  • 1Medical Oncology Department, INIBIC, A Coruña, Spain fernando.torres.andon@sergas.es.

Journal for immunotherapy of cancer
|February 24, 2026
PubMed
概括

工程化巨细胞表达化学抗原受体 (CAR-Mφ) 有效地准固体瘤. 这种新型细胞疗法在临床前模型中表现出显著的瘤回归,毒性最小,为未来的癌症治疗提供了希望.

关键词:
化学抗原受体 - - CAR免疫治疗是一种免疫疗法.骨髓状细胞是什么? 骨髓状细胞是什么?固体瘤是一个固体瘤.瘤微环境 - - 瘤微环境

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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports07:44

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The Tumor Microenvironment02:17

The Tumor Microenvironment

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
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