riboflavin 缺乏症在世界各地的高收入和低收入/中等收入国家的妇女和儿童中非常普遍
Liadhan McAnena1, Mary Ward1, Adrian McCann2
1Nutrition Innovation Centre for Food and Health, Ulster University, Coleraine, Northern Ireland, United Kingdom.
The Journal of nutrition
|February 24, 2026
概括
全球范围内, riboflavin 缺乏症在女性和儿童中普遍存在,在一些高收入国家影响了近一半,在低收入/中等收入国家影响了大多数. 迫切需要采取战略,以改善全球利博黄素的状况.
科学领域:
- 营养生物化学 营养生物化学
- 公共卫生 营养 公共卫生 营养
- 全球健康 全球健康
背景情况:
- рибофлавин (维生素B2) 对于代谢过程至关重要,它作为flavin mononucleotide和flavin adenine dinucleotide起作用.
- 由于人类研究中状态生物标志物的测量不频繁,利博夫拉缺乏的全球患病率在很大程度上是未知的.
研究的目的:
- 评估全球多个地区的生育年龄女性和儿童的 рибофлавин状况,包括高收入国家 (HIC) 和低收入/中等收入国家 (LMIC).
主要方法:
- 红细胞谷氨还原酶激活系数 (EGRac) 用于测量里博弗拉状态.
- EGRac值≥1.40表示缺陷;较高的值表示地位较低.
- 分析了来自爱尔兰,英国,柬埔寨,刚果民主共和国,西班牙,加拿大,马来西亚,老和乌干达的人口代表性和队列样本.
主要成果:
- 在HIC中, riboflavin 缺乏症很普遍:48%的爱尔兰女性和50%的英国女性 (18-45岁) 缺乏.
- 在LMIC中,缺乏率显著更高:马来西亚 (72%),柬埔寨 (82%) 和乌干达 (90%).
- 在英国儿童中,缺乏随着年龄的增长而增加,在LMIC儿童中,39%-75%是缺乏的,乌干达儿童表现出临床症状.
结论:
- рибофлавин 缺乏症是影响女性和儿童的全球重大健康问题.
- 这些发现强调,迫切需要以人口为基础的干预措施,以提高全球利博弗拉的地位.
- 由于其广泛的不良健康后果,解决 riboflavin 缺乏症至关重要.
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