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Updated: Feb 26, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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在和体外分析甘酸与人体单碳酸转运器1和4结合

Mona Alrasheed Bashir1,2,3, Chang-Sheng Shao1,2, Mohnad Abdalla4

  • 1CAS Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.

Proteins
|February 24, 2026
PubMed
概括

甘酸A (GAA) 直接与单碳酸盐输送体 (MCT1) 和 (MCT4) 相互作用,这对癌症代谢至关重要. 这项研究揭示了GAA.

关键词:
细胞热转移试验 (CETSA) 是指细胞热转移试验.ITDRF (异热剂量依赖指纹) 的使用甘酸是一种甘酸.分子对接的分子对接.分子动力学 (MD) 模拟单碳氧酸盐运输体的使用方法

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Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets10:16

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Published on: March 12, 2019

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The pharmacogenetics of drug transporters is increasingly recognized as a critical factor influencing interindividual variability in drug absorption, distribution, and elimination. These membrane-bound proteins regulate drugs' movement across cellular barriers by actively pumping them out (efflux) or facilitating their uptake (influx). Among the major transporter families, ATP-binding cassette (ABC) and solute carrier (SLC) transporters play particularly prominent roles. Genetic polymorphisms...
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In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
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