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Updated: Feb 26, 2026

Examination of Proteins Bound to Nascent DNA in Mammalian Cells Using BrdU-ChIP-Slot-Western Technique
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缺少ID3会改变DSB部位的染色质可访问性,并增加对HDAC抑制的脆弱性

Giuditta Della Corte1, Hossam Eldesouky1, Julia Puchan1

  • 1Division of Cancer Epigenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.

International journal of cancer
|February 24, 2026
PubMed
概括

抑制剂DNA结合3 (ID3) 损失通过影响双链断裂 (DSB) 部位的染色质可访问性来损害DNA修复. 将ID3损失与HDAC抑制相结合,为ID3缺陷癌症揭示了一个新的治疗策略.

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