肠道病原体通过免疫调节C. elegans中中央血清素信号的免疫调节来取代饥饿驱动的决策
Ying Lei1, Chao Chen2, Xu Zhan1
1Department of Pathophysiology, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Nature communications
|February 24, 2026
概括
病原体P. aeruginosa改变了C. elegans中的血清素信号,通过放大压力反应和优先考虑安全而不是寻找食物,取代了寻找食物的正常行为.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 动物行为 动物行为
背景情况:
- 动物将内部状态和肠道信号整合到生存决策中.
- 肠道细菌通过代谢线索对宿主决策的影响尚不清楚.
研究的目的:
- 研究肠道病原体P. aeruginosa如何影响Caenorhabditis elegans的宿主决策.
- 阐明血清素 (5-HT) 信号传递在感染期间调解肠与大脑通信中的作用.
主要方法:
- 利用C. elegans模型系统研究宿主-病原体相互作用.
- 研究了通过P. aeruginosa调节中央血清素信号的调节.
- 研究了肠道能量传感途径的激活及其对ADF5-HT神经元中化学受体SRI-36的影响.
主要成果:
- 禁食通常通过通过SRI-36和中度5-HT释放增加食物吸引力来促进冒险行为.
- 通过激活免疫-大脑轴,P. aeruginosa可以逆转这种情况,进一步放大SRI-36表达和ADF灵敏度.
- 这导致过度的5-HT释放,抑制食物吸引力,并优先考虑安全性.
结论:
- 在C. elegans中,P. aeruginosa通过调节中央血清激素信号来覆盖宿主决策.
- 一个肠到大脑机制存在,其中代谢和免疫信号汇聚在血清素上,以重塑行为策略.
- 这项研究揭示了病原体如何通过肠-大脑轴操纵宿主行为.
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