人类功能性大脑连接性的遗传景观
Bernardo de Apc Maciel1, Marijn Schipper1, Cato Romero2
1Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Nature communications
|February 24, 2026
概括
常见的遗传变异显著影响整个连接组的功能性大脑连接. 这些遗传因素影响大脑组织,认知功能和整体健康,突出显示了整个大脑的共同遗传效应.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 脑部成像 脑部成像
背景情况:
- 了解功能性大脑连接的遗传基础对于洞察大脑健康和疾病至关重要.
- 大脑电路的个体差异受遗传变异的影响.
研究的目的:
- 通过使用大规模数据集,研究功能性大脑电路的遗传结构.
- 识别与功能性大脑连接相关的特定基因和生物通路.
主要方法:
- 用一种质量无变的方法分析了28,159名受试者的功能性大脑电路.
- 使用高空间分辨率数据 (82个大脑区域) 检查了3321个区域间功能通路.
主要成果:
- 在33%的功能途径中,常见的遗传变异解释了个体差异.
- 72个显著的遗传关联揭示了大脑连接体中广泛的类效应.
- 这些关联与五个参与神经发育,心血管和认知过程的基因 (PAX8,EphA3,SLC39A12,THBS1,APOE) 有关.
结论:
- 功能性大脑连接差异的遗传成分在大脑中广泛共享.
- 遗传变异在大规模大脑组织中起着重要作用.
- 这些发现强调了遗传因素对认知功能和整体健康的重要性.
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