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Updated: Feb 26, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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Published on: November 9, 2020

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用于针对MYC和KRAS的向降解的异构功能蛋白质仿真聚合物

Max M Wang1,2,3,4, Mihai I Truica5,6, Brayley S Gattis1,3,4

  • 1Department of Chemistry, Northwestern University, Evanston, IL, USA.

Nature communications
|February 24, 2026
PubMed
概括

我们开发了HYDRAC,这是一个用于向蛋白质降解 (TPD) 的新型聚合物平台. HYDRAC有效地降低了MYC和KRAS等具有挑战性的疾病目标,扩大了TPD应用.

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