高高压和MASLD:融合机制和临床影响
Federico Capone1,2,3,4,5, Steffen P Häseli1,2, Luo Liu1,2
1Deutsches Herzzentrum der Charité, Department of Cardiology, Angiology and Intensive Care Medicine, Max Rubner Center for Cardiovascular Metabolic Renal Research (MRC), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Nature reviews. Cardiology
|February 24, 2026
概括
保存喷射分数 (HFpEF) 的心力衰竭和与代谢功能障碍相关的脂肪性肝病 (MASLD) 是由共同的代谢问题联系在一起的. 了解肝心轴对于管理这些相互关联的疾病至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 在全球范围内,心脏衰竭与保存的喷射分数 (HFpEF) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 正在增加,与肥胖和代谢综合征有关.
- 这些情况以前被单独研究,但现在被理解为系统代谢功能障碍的相关表现.
- 最近的证据强调了共同的风险因素和肝脏与心脏之间的双向通信通道.
研究的目的:
- 探索MASLD和HFpEF之间的流行病学和机制联系.
- 检查共享的代谢驱动因素,如脂毒性,元炎症和氧化应激.
- 讨论影响心脏功能的肝脏衍生的调解剂,并提出综合管理策略.
主要方法:
- 对MASLD-HFpEF连接的流行病学数据和机制研究的审查.
- 分析共享的代谢途径,包括脂毒性,元炎症和氧化应激.
- 对影响心脏的新兴肝脏衍生媒介 (肝激素,代谢物,细胞外囊泡) 的检查.
主要成果:
- MASLD和HFpEF具有共同的代谢驱动因素和危险因素.
- 肝脏和心脏之间存在一个动态的,双向的交叉通话.
- 肝脏衍生因素显著影响心脏结构和功能.
结论:
- 肝心轴对于理解MASLD和HFpEF之间的相互作用至关重要.
- 临床识别和管理需要综合的多器官方法.
- 重新思考心脏代谢疾病超越器官特定的孤岛对于改善患者的治疗结果至关重要.
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