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儿科尿路感染中的多抗药性尿病原体:多中心回顾性趋势分析 (2020-2024)
Esra Erdoğan1, Azize Yetişgen2, Serpil Doğan3
1Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Harran University, Şanlıurfa, Türkiye. esraerdogan@harran.edu.tr.
Naunyn-Schmiedeberg's archives of pharmacology
|February 24, 2026
概括
流行病和地震等公共卫生危机显著影响儿科尿路感染 (UTI) 病原体和抗菌素耐药性 (AMR). 这项研究追踪了土耳其儿童在这些破坏性时期尿病原体和AMR趋势的变化.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 大规模的公共卫生干扰,如流行病和自然灾害,可以显著改变医疗保健,病原体分布和抗菌素耐药性 (AMR) 的流行.
- 了解这些影响对于调整治疗策略和公共卫生反应至关重要.
研究的目的:
- 评估尿路感染患者 (UTI) 的住院儿科患者抗菌耐药性的尿路病原体概况和时间趋势.
- 为了比较不同时期的这些趋势:COVID-19大流行,2023年的卡拉曼马拉斯地震,以及土耳其的地震后阶段.
主要方法:
- 一项回顾性多中心研究包括1131名住院儿科患者 (0-18岁) 患有培养确认的尿路感染,从2020年1月到2024年12月.
- 根据EUCAST标准,标准微生物学方法用于病原体识别和抗菌敏感性测试 (AST).
- 在预定义的研究期内,分析了尿病原体分布和耐药性模式.
主要成果:
- 格拉姆阴性细菌占主导地位 (89.57%),其中大肠杆菌和Klebsiella spp. 作为最常见的病原体.
- 在研究期间观察到,对安比西林, ceftriaxone, ceftazidime 和 trimethoprim-sulfamethoxazole,大肠杆菌耐药性的显著增加 (p < 0.01).
- 克莱布西埃拉 spp. 的种类. 在地震期间 (p=0.021). 多种耐药性 (MDR) 现型在Serratia spp.,Citrobacter spp.,Enterobacter spp.和Pseudomonas spp.中最高.
结论:
- 在重大公共卫生中断期间,儿科尿路感染病原体耐药性模式的时间变化明显.
- 调查结果强调需要对抗药性耐药性的持续区域监测.
- 在面对系统性医疗保健压力因素的环境中,环境意识的经验性治疗策略至关重要.
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