季节性病毒改变空气污染对儿科喘息和喘的短期影响:一项时间序列研究
Sam Louman1,2,3, Karlijn J van Stralen4, Sophie van Vlijmen5
1Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Centre Groningen, Groningen, Netherlands. slouman@spaarnegasthuis.nl.
Environmental health : a global access science source
|February 24, 2026
概括
病毒循环,特别是犀牛病毒 (RV),改变了空气污染和儿科喘息相关疾病 (WAD) 之间的联系. 考虑到像RV这样的病毒,可以提高对污染的理解.
科学领域:
- 环境健康 环境健康
- 儿科呼吸系统医学 儿科呼吸系统医学
- 流行病学 流行病学
背景情况:
- 短期暴露于空气污染是已知的儿童喘息相关疾病 (WAD) 的触发因素.
- 以前的研究往往忽略了并发的病毒循环,可能会混或修改污染-WAD关联.
- 了解空气质量和病毒感染之间的相互作用对公共卫生至关重要.
研究的目的:
- 评估病毒循环是否会混或改变日常空气污染水平和儿科WAD急诊室 (ED) 访问之间的关联.
- 调查犀利病毒 (RV) 和呼吸道同胞病毒 (RSV) 在污染-WAD关系中的作用.
- 通过结合病毒数据,改善对空气污染对健康的影响的解释.
主要方法:
- 对12603次2-18岁儿童的WAD ED访问 (2016-2023) 的时间序列分析.
- 准鱼模型估计了每天NO2,PM2.5,PM10,O3和WAD ED访问之间的关联,调整了季节性,气象和花粉.
- 混杂和相互作用模型包含每周的RV和RSV阳性比率.
主要成果:
- 在基准模型中,对NO2和PM2.5的滞后暴露与增加的WAD ED访问有显著的关联.
- 在初步分析中调整病毒活性后,关联仍然相似.
- 相互作用模型显示,RV循环减弱了NO2,PM2.5和PM10对WAD ED访问的影响,而O3在低RV期间显示出负相关性.
结论:
- 循环性犀牛病毒 (RV) 修改,而不是混,短期空气污染和儿科WAD ED访问之间的关联.
- 结合病毒活动数据,可以更好地解释污染与健康的关联.
- 这种方法可能有助于解决之前空气污染研究中观察到的不一致性.
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