三级淋巴体结构与食道状细胞癌的复发风险降低和增强的抗瘤免疫力相关,对新辅助化学免疫疗法有病理性不完全反应
Yang Wo1, Tong Lu2,3, Zijiang Yang2
1Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Experimental hematology & oncology
|February 24, 2026
概括
三级淋巴体结构 (TLS) 的存在预测新辅助化学免疫疗法 (nCIT) 后食道状细胞癌 (ESCC) 患者的治疗结果更好. TLS与有利的免疫细胞概况和降低复发风险相关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 局部发达的食道状细胞癌 (ESCC) 患者通常对新辅助化疗免疫疗法 (nCIT) 缺乏反应,导致复发.
- 预后生物标志物对于ESCC患者而言是必要的,这些患者无法达到病理完整反应 (pCR).
- 三级淋巴体结构 (TLS) 是免疫细胞聚合物,在抗瘤免疫中具有潜在的作用.
研究的目的:
- 在非pCR ESCC患者中调查TLS的预后价值.
- 分析与非pCR ESCC中TLS存在相关的免疫细胞概况.
主要方法:
- 基于TLS状态的临床病理特征,复发和存活率的分析.
- 单细胞测序以评估免疫细胞透,功能和相互作用.
- 大量RNA测序和多重免疫组织化学验证发现.
主要成果:
- 患有TLS (TLS+) 的患者的复发率较低,生存率比没有TLS的患者更好 (TLS-).
- TLS+组显示丰富的免疫疗法响应性免疫细胞具有高激活和低疲劳.
- TLS促进了瘤反应性T细胞,B细胞和抗原呈现细胞的空间同位化和相互作用.
结论:
- TLS状态是非pCR ESCC中术后复发的独立预测因素.
- 存在TLS与改善的免疫细胞组成,功能和相互作用相关.
- TLS可能代表专门的免疫,增强ESCC的抗瘤反应.
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