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国际,前性的COSMOS (CytOSorb® 治疗重症患者) 注册表:来自前300名患者的结果

Ricard Ferrer¹, Matthias Thielmann², Moritz Unglaube³

¹Intensive Care Department, Vall d'Hebron University Hospital, Shock, Organ Dysfunction and Resuscitation Research Group (SODIR), Barcelona, Spain. ricard.ferrer@vallhebron.cat.

Journal of anesthesia, analgesia and critical care

|February 24, 2026

概括

这项研究表明,CytoSorb® (CS) 治疗重症患者的临床标志物得到改善,与历史估计相比,死亡率降低. 由于观测设计,需要进一步研究.

科学领域:

关键护理医学关键护理医学
身体外疗法身体外疗法
炎症管理炎症管理

背景情况:

血液净化在危急病患者中被探索,以控制炎症并消除在狂犬病溶解中的肌球蛋白等毒素.
目前关于临床益处的证据有限,需要进一步调查.

研究的目的:

为了跟踪CytoSorb® (CS) 使用模式和重症监护机构的患者结果.
在现实环境中评估CS治疗的安全性和有效性.

主要方法:

国际前性COSMOS注册表在22个地点注册了300名成年患者.
数据包括在CS治疗之前,期间和之后的临床评估,以及90天的随访.
统计分析涉及描述性统计数据和配对测试,以比较治疗前和治疗后的值.

主要成果:

常见的适应症包括败血性休克 (48.3%),狂肠分裂 (12.8%) 和心脏性休克 (11.5%).
脑神经系统治疗改善了液体平衡,减少了对北上腺素的需求,并增加了P/F比率 (p < 0.0001).
集中治疗室死亡率为33.1%,低于严重性得分预测的水平;没有报告与设备相关的严重不良影响.

结论:

在重症监护中使用真实世界的CS显示了临床和实验室参数的改善.
结果表明潜在的好处,但由于观察设计,应谨慎解释.
观察到的死亡率低于具有类似严重性得分的患者的历史估计.

关键词:

吸附方式吸附方式吸附方式血液的净化血液的净化细胞吸收细胞吸收.血液吸收的吸收方式血 perfusion 输血输血输血输血输血输血输血输血过度炎症是一种超级炎症.肝功能衰竭肝功能衰竭登记处登记处登记处登记处拉布多溶解是什么意思败血症这是一种败血症.败血症的冲击是一个令人震惊的结果.

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