运动训练改变了癌症携带雄性小鼠的昼夜时钟动态
Loreana Sanches Silveira1, Edson Alves de Lima Junior1,2, José Cesar Rosa Neto1
1Immunometabolism Research Group, Institute of Biomedical Sciences, University of Sao Paulo (USP), Sao Paulo, Brazil.
Physiological reports
|February 25, 2026
概括
一致的运动时间提高了肺瘤中昼夜钟基因节律性. 这种时间运动方法可能为癌症治疗提供非药物辅助疗法.
科学领域:
- 时间生物学 时间生物学
- 癌症研究 癌症研究
- 运动生理学 运动生理学
背景情况:
- 循环时钟机制对于癌症的发展和进展至关重要.
- 恶性细胞可以破坏核心时钟基因表达和同步.
- 运动会影响昼夜节律,但其对瘤节律性的影响尚不清楚.
研究的目的:
- 在肺癌小鼠模型中调查运动时间是否影响昼夜基因表达和瘤生长.
- 为了确定固定时间和交替时间运动对瘤节律性的影响.
主要方法:
- 患有易斯肺癌 (LLC) 的雄性C57BL/6J小鼠进行了3周的跑步机炼.
- 运动是在固定的Zeitgeber时间 (ZT2) 或交替时间 (ZTAlt) 进行的.
- 瘤生长,时钟基因表达 (Per1,Per2,Per3,Rev-Erbα) 和TNF-α在六个昼夜时间点中使用Cosinor分析进行了分析.
主要成果:
- 固定时间运动 (ZT2) 显著增加了瘤组织中Per2,Per3和Rev-Erbα表达节奏的幅度.
- 在交替时间炼组 (ZTAlt) 中没有观察到节律增强.
- 瘤坏死因子-α (TNF-α) 缩在ZT2组中发生了转移,这表明时间免疫调节.
结论:
- 一贯定时的运动增强了瘤昼夜时钟基因的节律性.
- 每天在同一时间进行炼,显示出在癌症治疗中作为非药物辅助疗法的潜力.
相关概念视频
02:19Circadian Rhythms and Gene Regulation
4.6K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.6K
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
423
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
423
02:45Biological Clocks and Seasonal Responses
41.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
41.8K
02:43Mouse Models of Cancer Study
6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K