孕妇流感感染和怀孕期间接种疫苗对分娩结果的影响
Xueyan Zhang1, Goundappa K Balasubramani1, Helen Eleni Aslanidou D'Agostino1
1From the Department of Epidemiology, and.
The Pediatric infectious disease journal
|February 25, 2026
概括
感染流感的孕妇面临更高的不良分娩结果的风险,特别是在怀孕早期. 然而,在怀孕期间接种流感疫苗可以显著降低低出生体重和早产的风险,保护母亲和婴儿.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 围产期健康 围产期健康
背景情况:
- 孕妇有较高的风险发生严重的流感并发症.
- 孕产妇流感感染和接种疫苗可以影响分娩结果.
- 感染或接种疫苗的时间可能起着至关重要的作用.
研究的目的:
- 调查孕妇流感感染和怀孕期间接种疫苗以及不良分娩结果之间的联系.
- 检查流感感染或接种疫苗的时间对这些结果的影响.
主要方法:
- 对42,689对母婴对 (2012-2019) 的回顾性队列研究.
- 使用了宾夕法尼亚州的电子健康记录.
- 采用考克斯回归与时间变化的暴露分析.
主要成果:
- 怀孕期间的流感感染增加了剖腹产,低出生体重,非常低出生体重,早产和极度早产的风险,特别是在头三个月.
- 母体流感疫苗接种与低出生体重,非常低出生体重,早产和极度早产的风险显著降低有关.
- 在各种出生结果指标中观察到接种疫苗的好处.
结论:
- 怀孕早期的流感感染对不利的出生结果构成重大风险.
- 在怀孕期间接种流感疫苗可以有效降低低出生体重和早产的风险.
- 建议在怀孕期间鼓励早期接种流感疫苗,以保护母亲和婴儿的健康.
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