巴图文松缓解硫酸诱导的小鼠性结肠炎:一个网络药理学与实验研究结合实验研究
Sun Yan1, Zhou Haozheng2, Feng Jianhui2
1College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000, China.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
|February 25, 2026
概括
(Pulsatilla开) 通过减少炎症,有效地治疗小鼠的性结肠炎. 它通过抑制收费类受体4/核因子-kappa B (TLR4/NF-κB) 途径而起作用,为其传统使用提供了科学基础.
科学领域:
- 综合医学和药理学综合医学和药理学
- 胃肠道学和免疫学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 传统中医药,如Baitouweng Tang (Pulsatilla开,PD),已用于治疗肠道疾病.
研究的目的:
- 为了阐明DP的抗炎机制在硫酸 (DSS) 诱导的UC小鼠模型中.
- 整合网络药理学预测与机械洞察力的实验验证.
主要方法:
- 在C57BL/6小鼠中使用循环DSS给药建立了慢性UC模型.
- 接受治疗的小鼠患有低剂量或高剂量的PD,并从临床和组织病理上评估了疾病的严重程度.
- 量化了血清细胞因子,并使用网络药理学来预测PD的点,重点关注TLR4/NF-κB通路,然后通过实验验证.
主要成果:
- 治疗PD显著改善了UC症状,减少了疾病活性,改善了结肠组织学.
- 通过降低促炎性细胞因子 (IL-6,TNF-α) 和增加抗炎性IL-10来重新平衡PD系统性炎症.
- 网络药理学确定了TLR4/NF-κB通路作为一个关键目标,实验验证证证了PD抑制TLR4和NF-κB上调.
结论:
- 通过抑制TLR4/NF-κB信号通路,PD表现出对实验性UC的保护作用.
- 这种抑制导致炎症反应的减弱,为PD在治疗肠道疾病中的传统使用提供了现代药理基础.
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