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时间限制饮食对儿童血压的影响:一个集群随机对照试验
Xiaofei Wu1, Jingkun Miao2, Zhilian Peng3
1Department of Epidemiology and Biostatistics, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, People's Republic of China.
儿童和青少年的时间限制饮食 (TRE) 在12个月内显著降低了血压 (BP). 一个12小时的饮食窗口,特别是晚上8点之前的饮食,显示了最实质性的血压降低效应.
科学领域:
- 儿科健康 儿科健康
- 心血管研究研究心血管研究
- 营养科学 营养科学
背景情况:
- 儿童和青少年血压升高是一个越来越令人担忧的问题.
- 需要进行干预措施来管理儿科患者的高血压.
- 时间限制饮食 (TRE) 是一种饮食方法,具有潜在的代谢益处.
研究的目的:
- 评估时间限制饮食 (TRE) 干预措施降低儿童和青少年血压的安全性和有效性.
- 在12个月的时间内,比较两个TRE协议与对照组.
主要方法:
- 一个为期12个月的,三臂集群随机对照试验,涉及192名患有高血压的儿童和青少年.
- 参与者被分配到晚上8点前吃饭的TRE (TREa),没有固定餐时间的TRE (TREb) 或对照组.
- 分析采用混合效应模型,考虑聚类和多次归算缺失数据.
主要成果:
- 两个TRE组在12个月后显示出系统血压 (SBP) 的显著降低.
- TREa组经历了最显著的SBP降低 (-7.03 mmHg) 和腹压血压 (DBP) 降低 (-4.09 mmHg).
- 与对照组相比,TREa组的DBP变化明显不同.
结论:
- 12小时的进食窗口,特别是当最后一顿饭在晚上8点之前时,可能会降低患有高血压的儿科患者的血压.
- 研究结果表明,TRE是儿童和青少年血压管理的可行策略.
- 考虑研究设计 (集群随机化) 和消耗对于解释很重要.
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