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Updated: Feb 26, 2026

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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Published on: February 17, 2023

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空间缩的腺基编辑器有效地纠正了基细胞中的PLP1突变

Chi Zhang1, Ke Ye1, Yafang Shang2

  • 1Department of Histoembryology, Genetics and Developmental Biology, Shanghai Key Laboratory of Reproductive Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Nucleic acids research
|February 25, 2026
PubMed
概括

我们开发了一种空间缩的腺基编辑器 (cABE),以改善基细胞 (OLs) 中的基因编辑. 这一策略增强了导致Pelizaeus-Merzbacher病 (PMD) 的突变的纠正,为这种髓疾病提供了潜在的治疗方法.

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