精子生物能量可塑性和代谢适应性在通往受精的旅程中
Ruizhi Xue1,2, Ruikang Shi2, Xiaobin Yuan2
1Department of Urology and Andrology, Xijing Hospital of the Air Force Medical University, Xi'an, China.
Molecular reproduction and development
|February 25, 2026
概括
精子体表现出动态的代谢可塑性,转移能量路径,如糖解和氧化酸化,这对男性生育能力至关重要. 了解这些生物能量适应,为诊断和治疗男性不孕症提供了新的途径.
科学领域:
- 生殖生物学 生殖生物学
- 精子代谢 精子代谢
- 男人不孕不育的情况
背景情况:
- 男性不孕症影响全球健康,精子生物能学在受精中发挥着关键作用.
- 精子在整个生命周期中经历了显著的代谢变化,影响了它们的功能.
研究的目的:
- 审查精子细胞从发育到受精的动态代谢可塑性.
- 探索在精子生成过程中代谢重编程,表观遗传学和细胞命运之间的联系.
- 了解精子如何在不同的生殖道环境中适应它们的能量策略.
主要方法:
- 对精子生物能学当前知识的系统审查.
- 分析代谢重编程及其与表观遗传重塑的合.
- 检查精子的代谢适应在 epididymal 成熟,储存和穿越女性生殖道期间.
主要成果:
- 涉及糖解和氧化酸化振荡的代谢重编程与精子发生过程中的表观遗传重塑和细胞命运有关.
- 流行性成熟赋予了代谢灵活性,而储存则涉及静止.
- 精子动态地适应女性通道中的能量策略,利用阴道中的糖解和两个通道进行电容和体反应.
结论:
- 精子的代谢适应性是受精能力的一个基本决定因素.
- 对这些生物能量机制的进一步研究可以导致新的诊断生物标志物和治疗男性不孕症的治疗策略.
- 关于在特定的生殖中占主导地位的代谢途径,仍存在争议.
相关概念视频
Fertilization
92.3K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
92.3K
Spermatogenesis
124.0K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
124.0K
Spermatogenesis
10.1K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
10.1K
Sperm Transport
4.0K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
The maturation phase occurs in the epididymis, where sperm...
4.0K
Sperm Structure and Semen Composition
12.2K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
12.2K
Energy Budgets
11.0K
Organisms must balance energy intake with the energy required for growth, maintenance and reproduction. These trade-offs result in a variety of survivorship and reproductive strategies, including semelparity and iteroparity. Semelparous species, like annual plants, have only one reproductive episode in their lifetimes and consequently have short lifespans. Iteroparous species, by contrast, have many reproductive events during their lifetimes but have relatively few offspring. These two...
11.0K


