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在CMS4结肠腺癌中,ATP23的抗瘤和免疫功能基于机器学习计算框架

Yafei Yin¹, Huimin Zhang¹, Shuai Li¹

¹Department of Gastroenterology, The Second Qilu Hospital of Shandong University, Jinan, China.

|February 25, 2026

概括

ATP23是结肠腺癌 (COAD) 的潜在预后标志物. 较低的ATP23表达与预后不佳和免疫逃避相关,影响治疗疗效.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

共识分子亚型 (CMS) 4和BRAF突变是结肠腺癌 (COAD) 的不良预后指标.
虽然BRAF突变在CMS1中很常见,但它们也在CMS4 COAD中发现,这是一种缺乏广泛的机械和预后研究的亚型.
研究BRAF突变CMS4COAD的预后意义和潜在机制至关重要.

研究的目的:

为了研究ATP23表达在结肠腺癌 (COAD) 的预后价值.
探索ATP23表达与共识分子亚型 (CMS) 4和COAD中的BRAF突变之间的相关性.
阐明ATP23影响COAD进展和瘤微环境的潜在机制.

主要方法:

从六个公开的COAD数据集中对转录组概况和临床数据进行了回顾性分析.
卡普兰-梅尔生存分析和生物信息学,以评估ATP23表达与患者生存的相关性.
在体外实验中验证ATP23在COAD细胞行为和免疫细胞功能中的作用.

主要成果:

在COAD瘤组织中,ATP23的表达显著降低,特别是在CMS4亚型中.
较高的ATP23水平与改善患者存活率和抑制COAD细胞增殖,迁移和入侵有关.
减少ATP23表达可能会损害T细胞氧化酸化,促进免疫逃避的微环境,并可能降低治疗疗效.

结论:

ATP23作为结肠腺癌 (COAD) 的潜在预后生物标志物.
减少ATP23表达与免疫抑制性瘤微环境和较差的结果有关.
向ATP23可能为COAD患者提供治疗策略,特别是CMS4亚型患者.

关键词:

它们是ATP23和ATP23 结肠腺癌结肠腺癌.免疫反应的免疫反应.预测生物标志物预测生物标志物

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