关于社区抗生素处方的区域处方方体特定变异的国家回顾性研究加拿大,2019-2023年
Kahina Abdesselam1, Drew Greydanus1, Pia Kaur Muchaal1,2
1Antimicrobial Resistant Task Force, Public Health Agency of Canada, Ottawa, Ontario, Canada.
BMJ public health
|February 25, 2026
概括
在加拿大各省和处方者类型之间,抗菌素处方有很大差异. 定制的管理干预措施对于改善抗微生物药物的使用和打击加拿大的抗微生物药物耐药性至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗菌素耐药性 (AMR) 是一个关键的全球和加拿大公共卫生问题.
- 不必要或低于最佳的抗菌剂使用 (AMU) 推动了AMR,需要量身定制的区域解决方案.
- 了解抗生素处方的变化是促进明智的处方和有效管理的关键.
研究的目的:
- 分析2019年至2023年加拿大的门诊抗生素处方趋势.
- 为了识别抗生素处方的省际和处方者类型变化.
- 确定针对抗微生物药物管理干预措施的目标.
主要方法:
- 使用IQVIA的地理处方监测数据库 (2019-2023) 进行了回顾性观察研究.
- 处方费率按省份,处方专业和AWaRe分类进行分层.
- 对人口和时间因素进行调整的负二项式回归模型.
主要成果:
- 观察到重要的省级处方差异,PEI/NFLD的比例最高,BC的最低.
- 在COVID-19大流行期间,处方率下降,部分反弹.
- 北克显示了最高的储备抗生素使用率;BC显示最低. 家庭医生主导了处方;牙医和药剂师也做出了贡献. 诺基诺的使用量下降,而beta-lactamase抑制剂的处方在流行后增加.
结论:
- 处方模式的变化突出了针对性抗微生物药物管理的机会.
- 将管理范围扩大到非医生处方者,并实施特定区域的战略至关重要.
- 改善AMU和解决加拿大的AMR需要一个多方面的方法.
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