渐进式腔 - - 对梯度生物打印新技术与现有的挤出方法进行比较
Franz Moser1, Shiva Rahmani1, Tomasz Jungst1
1Department for Functional Materials in Medicine and Dentistry Institute of Functional Materials and Biofabrication University of Würzburg and Key Lab Polymers for Medicine of the Bavarian Polymer Institute (BPI) Würzburg Germany.
Engineering in life sciences
|February 25, 2026
概括
渐进式腔为基于挤出的生物打印提供了更高的精度,特别是用于创建材料梯度. 这种新兴的方法在精度和保真方面优于传统的注射器和气动挤压技术,用于先进的生物制造应用.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 生物制造的生物制造
背景情况:
- 基于挤出的生物打印对于生物制造至关重要.
- 目前的方法限制了打印保真度和渐变应用.
- 已建立的技术包括气动和注射器挤出.
研究的目的:
- 将渐进式空腔与已知的挤出方法进行比较.
- 评估准确性,精度和流量配置功能.
- 评估适用于印刷材料梯度的适用性.
主要方法:
- 比较渐进式腔,气动挤压和注射器.
- 测试了35%的Pluronic F127.7的挤出方法
- 模拟的流量配置,材料依赖性和硬件转移.
主要成果:
- 渐进式空腔在梯度印刷方面表现出卓越的性能.
- 注射器需要更多的代才能稳定地挤出.
- 气动挤出提供了大量输出,但精度较低.
结论:
- 渐进式腔对于梯度生物打印具有优势.
- 这种方法提高了生物制造的准确性和精度.
- 新兴技术提供了超越既定技术的改进能力.
更多相关视频
相关概念视频
Bioreactor Controls-II
In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...
Upstream Processing
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...


