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产生和调节细胞内硫化物和多硫化物的酶:机械学见解和抑制剂

Ko Hirabayashi¹, Eita Sasaki¹, Hisashi Ohno¹

¹Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.

Frontiers in physiology

|February 25, 2026

概括

活性硫种 (RSS) 对生理过程至关重要. 本综述详细介绍了产生RSS的酶,它们的机制,以及潜在的治疗抑制剂,用于研究和医学.

科学领域:

生物化学生物化学
分子生物学分子生物学
生理学生理学生理学

背景情况:

活性硫种 (RSS),包括化硫和多化硫,对哺乳动物生理学至关重要,影响氧化还原信号,代谢和炎症.
关键的酶,如环氨酸β-合成酶 (CBS),环氨酸γ-酶 (CSE),3-mercaptopyruvate硫转移酶 (3MST) 和CARS2都参与了内源性RSS的产生.
线粒体酶如硫化物:氨酸氧化还原酶 (SQOR),ETHE1和硫酸硫酸转移酶 (TST) 也调节了RSS水平.

研究的目的:

提供有关RSS的生产和调节所涉及的酶的全面概述.
专注于这些酶的反应机制.
讨论针对这些酶的选择性抑制剂,用于研究和治疗应用.

主要方法:

关于RSS相关的酶途径和机制的文献综述.
负责硫化 (H2S),硫化和多硫化生成和代谢的酶的分析.
收集有关已知抑制剂及其潜在应用的信息.

主要成果:

详细描述CBS,CSE,3MST,CARS2,SQOR,ETHE1和TST在RSS代谢中的作用.
阐明这些酶所使用的反应机制.
选择性抑制剂作为RSS研究和潜在治疗的有价值工具的识别.

结论:

像CBS,CSE,3MST,CARS2,SQOR,ETHE1和TST这样的酶是RSS恒温的核心.
了解它们的机制和开发选择性抑制剂对于推进RSS研究和探索治疗途径至关重要.

关键词:

线粒体呼吸系统的呼吸过程硫化物可能是什么?聚硫化物聚硫化物蛋白质硫化物蛋白质.有反应性的硫物种.选择性抑制剂的选择性抑制剂硫化物氧化的硫化物.转硫化途径的转硫化途径

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