集成的单细胞和空间转录学揭示了胃上皮质谱系进展的分化驱动因素
Xuyu Chen1, Xin Jiang1, Siying Wang2
1Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Frontiers in immunology
|February 25, 2026
概括
这项研究确定UPP1是胃癌 (GC) 发展的关键调节者,将Helicobacter pylori (HP) 炎症与WNT信号联系起来. UPP1可以作为GC的预后生物标志物和治疗标.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 胃癌 (GC) 的进展包括慢性胃炎和肠道转化 (IM),其中Helicobacter pylori (HP) 作为驱动因素.
- 连接炎症与GC恶性转变的分子机制尚未完全理解.
研究的目的:
- 研究细胞异质性,分化途径和胃癌发生过程中的分子媒介.
- 确定关键调节者,将HP驱动的炎症与GC进展中的WNT信号联系起来.
主要方法:
- 综合单细胞RNA测序和从GC的各个阶段的胃粘膜样本的空间转录组学,包括HP+和HP-病例.
- 有机体实验和基因操纵 (淘汰赛/淘汰赛) 来评估UPP1的功能.
- 对UPP1表达与GC阶段和患者存活率的临床相关性分析.
主要成果:
- 肠道代谢 (IM) 表皮表现出增强的WNT信号,促进瘤进展,而HP相关的炎症激活NF-κB信号.
- UPP1在恶性和HP阳性表皮上升调,与进展和生存率差相关.
- UPP1促进肠道分化,其敲击降低了GC细胞迁移和克隆性.
结论:
- UPP1是表皮重编程和IM的关键调节者,将HP诱导的炎症与GC中的WNT介导的分化联系起来.
- UPP1代表了胃癌的潜在预后生物标志物和治疗标.
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