相关实验视频

Updated: Feb 26, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

瘤中的毛囊的免疫微环境免疫疗法免疫疗法

Bo Li¹, Sitong Jiang², Fan Yang³

¹Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.

ImmunoTargets and therapy

|February 25, 2026

概括

瘤免疫疗法可以通过破坏毛囊引起脱发,从而导致脱发.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

瘤免疫疗法对固体瘤有效,但会导致皮肤和卵泡不良事件.
毛囊免疫微环境通过免疫细胞和细胞因子调节头发循环.
免疫检查点抑制剂破坏了这种平衡,导致毛囊毒性,如脱发.

研究的目的:

阐明瘤免疫疗法诱导卵泡毒性的机制.
确定关键的监管节点,以制定针对免疫疗法诱导的脱发症的有针对性的干预措施.

主要方法:

对免疫检查点抑制剂的反应中免疫细胞 (T细胞,巨细胞) 激活的分析.
评估细胞因子网络的改变,包括瘤亡因子-alpha.
对托尔类受体/核因子-卡帕-B信号通路激活的研究.

主要成果:

免疫检查点抑制剂激活T细胞并促进促炎性巨细胞两极分化.
观察到炎症性细胞因子的升级,例如瘤亡因子-α.
托尔类受体/核因子-卡帕B通路的激活有助于卵泡毒性.

结论:

了解免疫疗法诱导的卵泡毒性机制至关重要.
针对特定的调节节点可以减轻诸如脱发等不良事件.
目前的治疗依赖于局部皮质类固醇和免疫调节剂.

关键词:

毛囊是毛囊中的一个毛囊.免疫微观环境免疫微环境瘤免疫疗法免疫疗法

更多相关视频

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.