全球腺炎辅助性临床试验中的种族差距的最新情况
Camila R Marquez1,2, Aditya Joshi1,3, Lauren Gawey1
1Department of Dermatology, University of Washington School of Medicine, Seattle, WA, USA.
Skin appendage disorders
|February 25, 2026
概括
黑人和西班牙裔/拉丁裔患有腹炎 (HS) 的个体在临床试验中仍然代表性不足,尽管报告情况有所改善. 未来的HS试验需要全球的地点多样性和分层分析,以确保公平的代表性.
科学领域:
- 皮肤病学 皮肤病学
- 临床试验 临床试验
- 健康 公平 卫生 公平
背景情况:
- 补腺炎 (HS) 不成比例地影响少数群体,包括黑人和西班牙裔个人.
- 这些群体在HS临床试验中的代表性仍然有限,这阻碍了研究结果的概括性.
研究的目的:
- 评估参与者在最近的性炎 (HS) 临床试验中的种族代表性和报告.
- 为了确定在HS研究中招生和地理分布的差异.
主要方法:
- 在2019年至2025年期间完成的2期和3期HS试验使用ClinicalTrials.gov.gov被确定.
- 从试验结果和出版物中提取了参与者的民族种族数据,并使用PubMed来补充缺少的信息.
主要成果:
- 白人参与者占17项试验中2,652个人的76.2%,黑人/非洲裔美国人为13.0%,西班牙裔/拉丁裔为5.2%.
- 报告西班牙裔/拉丁裔种族特别低 (58.8%的试验).
- 试验主要位于北美 (100%) 和欧洲 (70.6%),非洲,亚洲和南美洲的代表性有限.
结论:
- 尽管在HS试验中种族和种族报告有所改善,但黑人和西班牙裔/拉丁裔患者的代表性仍然不足.
- 缺乏全球试验场的多样性,特别是在非洲,亚洲和南美洲,导致人口不平衡.
- 未来的HS临床试验应优先考虑全球地点的多样性,并进行分层分析,以确保在不同人群中进行公平评估.
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