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大脑形态学对腰部疼痛风险的影响:孟德尔的随机化研究

Ziqun Liu^1,2, Yawei Li^1,2, Yuliang Dai^1,2

¹Department of Spine Surgery, Second Xiangya Hospital of Central South University, Changsha, People's Republic of China.

Journal of pain research

|February 25, 2026

概括

减少大脑大小,特别是全球皮质表面积和额头-胸膜体积,与增加腰部疼痛 (LBP) 风险有因果关系. 这表明LBP脆弱性的神经解剖学基础.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
疼痛研究疼痛研究

背景情况:

腰部疼痛 (LBP) 是一个重要的全球健康问题,受遗传和中枢神经系统因素的影响.
虽然大脑结构和LBP之间存在关联,但因果关系尚未得到充分确立.
了解LBP的神经解剖学基础对于开发有效的干预措施至关重要.

研究的目的:

研究大脑形态特征与腰部疼痛 (LBP) 风险之间的因果关系.
确定可能影响对LBP易感性的特定大脑结构.
为中央神经解剖学在疼痛脆弱性中的作用提供证据.

主要方法:

采用了两个样本的门德尔随机化 (MR) 分析.
全基因组关联研究 (GWAS) 总结统计数据被用于基因仪器.
数据来源包括ENIGMA,英国生物银行和FinnGen联盟的大脑特征和LBP.

主要成果:

经过校正后,十个大脑形态学特征显示了与LBP的因果关系.
较大的全球皮层表面积和额头部,部区域,带膜皮层和丘脑的体积显示出保护作用.
对于硫形态特征,没有发现因果关系.

结论:

遗传性减少的全球皮质表面积和前额 - thalamic大脑体积与较高的LBP风险有因果关系.
这项研究提供了新的证据,证明中枢神经解剖学对腰部疼痛脆弱性的贡献.
大脑形态测量在个体对LBP的倾向中发挥着重要作用.

关键词:

大脑皮质结构大脑皮质结构大脑形态测量大脑硫形态的形态学大脑体积的大脑体积腰部疼痛腰部疼痛腰部疼痛门德尔的随机化是门德尔的随机化

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