在自闭症谱系障碍中使用Risperidone的药物基因组学:一篇小小的回顾
Caroline Rafaelli de Lima Honório1, Beatriz Gafanhão Bobadilha1, Melina Pinheiro Conscetta1
1Department of Morphology and Basic Pathology - Medical School, Faculdade de Medicina de Jundiaí, Jundiaí, Brazil.
Frontiers in pharmacology
|February 25, 2026
概括
药物遗传学因素,特别是CYP2D6,影响自闭症谱系障碍 (ASD) 儿童的RISPERIDONE有效性和副作用. 虽然对个性化治疗有希望,但目前在ASD中使用Risperidone的PGx应用存在局限性.
科学领域:
- 药物基因组学 药物基因组学
- 神经心理药理学神经心理药理学
- 自闭症谱系障碍 (ASD) 研究研究
背景情况:
- 里斯佩里是ASD刺激症的关键治疗方法,但患者的反应和副作用差异很大.
- 药物遗传学 (PGx) 研究研究了对这种变异性的遗传影响,重点关注代谢,输送器和神经递质通路.
- 了解这些遗传因素对于优化儿童ASD群体里斯比里治疗至关重要.
研究的目的:
- 审查和综合与儿童和青少年患有自闭症的RISPERIDONE结局相关的当前PGx发现.
- 为了确定RISPERIDONE药理动力学,药理动力学和毒性的关键遗传预测因素.
- 讨论在ASD临床实践中实施PGx的挑战和未来方向.
主要方法:
- 关于ASD中RISPERIDONE的现有药物基因组研究的叙述性小审查.
- 对影响RISPERIDONE代谢,运输和神经递质通路的遗传变异的证据综合.
- 讨论方法问题,临床指南和新兴的PGx方法.
主要成果:
- CYP2D6 是对RISPERIDONE药理动力学和毒性的最强的预测因子.
- 与ABCB1,DRD3,HTR2A,HTR2C和LEP等基因的药理学关联不一致,并且基于小型研究.
- 证据表明PGx可以告知RISPERIDONE的使用,但由于队列大小和不一致的研究结果而面临限制.
结论:
- 药物基因组学有望为调整ASD的RISPERIDONE治疗量身定制,提高安全性和有效性.
- 对CYP2D6的基因定型是预测RISPERIDONE结果的强有力的起点.
- 需要进一步的研究和方法进步,以克服目前的局限性,并充分实施PGx在ASD治疗临床决策.
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