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针对先天性免疫细胞的创新方法,以促进器官移植耐受性

Chiyoshi Toyama¹, Angus W Thomson^1,2

¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, United States.

Frontiers in transplantation

|February 25, 2026

概括

尽量减少免疫抑制对于长期移植生存至关重要. 准先天性免疫细胞提供了精确疗法,通过调节免疫反应而无需全球抑制来促进移植耐受性.

科学领域:

免疫学免疫学免疫学
移植生物学移植生物学
精准医学是一门精准的医学.

背景情况:

尽量减少系统性免疫抑制,同时实现长期的异构移植存活是移植的一个重大挑战.
天生的免疫细胞,不仅仅是适应性免疫,在编排异种移植的排斥和耐受性方面发挥着至关重要的作用.
最近的进展揭示了先天免疫细胞的异质性,提供了新的治疗点.

研究的目的:

审查用于调节先天性免疫细胞以促进移植耐受性的创新策略.
探索针对特定的先天性免疫细胞子集和检查点的精确疗法.
讨论重新编程allograft微环境的新方法.

主要方法:

对单细胞RNA测序和空间转录组学近期进展的回顾.
针对骨髓质抑制检查点的策略分析 (例如,LILRB,SIGLEC-E).
对代谢重编程,CRISPR/Cas9基因编辑和采用细胞转移的评估.

主要成果:

天生的免疫细胞是全移植排斥和耐受性的关键调节者.
准髓质抑制检查点可以诱导耐受性表型.
调节代谢途径和使用基因编辑为免疫控制提供了潜在的潜力.
监管性髓状和先天性淋巴细胞的采用转移显示出有希望的结果.

结论:

针对先天免疫力的精密疗法代表了移植的范式转变.
选择性调节天生的免疫反应性可以导致移植耐受性.
重编程allograft微环境是改善移植结果的关键.

关键词:

树突细胞是一种树突细胞.免疫疗法免疫疗法天生的淋巴细胞是先天性淋巴细胞.巨细胞是什么?巨细胞是什么?单细胞 (Monocytes) 是一种单细胞.骨髓状细胞是骨髓状细胞的组成部分.来自骨髓细胞的抑制细胞.自然杀手细胞是自然杀手细胞.

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