血清尿酸与肌素的比率与2型糖尿病的运动功能障碍独立相关:一个横截面研究
Jie Peng1, Shangyan Liang2, Xiaoyun Tang1,3
1Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|February 25, 2026
概括
较低的血清尿酸与肌素比率 (SUA/Cr) 与2型糖尿病患者中运动功能障碍的风险较高有关. 这一发现突出了SUA/Cr作为糖尿病神经损伤的独立预测因子.
科学领域:
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
- 神经学 神经学
背景情况:
- 糖尿病外围神经病变是2型糖尿病的常见并发症.
- 运动功能障碍是小纤维神经病变的早期指标,影响了相当一部分糖尿病患者.
- 血清尿酸与肌素的比率 (SUA/Cr) 是一个潜在的生物标志物,但它与运动功能障碍的关联需要进一步研究.
研究的目的:
- 调查2型糖尿病患者血清尿酸与肌素比率 (SUA/Cr) 和运动功能障碍之间的关联.
- 确定SUA/Cr是否是该人群中运动功能障碍的独立预测因子.
主要方法:
- 一项涉及781名2型糖尿病患者的横截面研究.
- 根据SUA/Cr水平,参与者被分为三个分层.
- 使用SUDOSCAN评估从手和脚的汗水的电化学导电性 (ESC).
主要成果:
- 随着SUA/Cr tertiles (65.0%,57.6%,48.9%) 的增加,运动功能障碍的患病率下降.
- 较低的SUA/Cr水平显著与动功能障碍的风险增加有关 (p < 0.001).
- 在多变量调整后,降低的SUA/Cr仍然是动功能障碍的显著独立预测因子 (OR=1.646,p=0.018).
结论:
- 血清尿酸与肌素的比率 (SUA/Cr) 独立地与2型糖尿病患者的运动功能障碍有关.
- 较低的SUA/Cr可以作为一种有价值的生物标志物,用于识别患上气运动功能障碍和潜在的糖尿病外围神经病变的风险较高的人.
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