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氧化物纳米颗粒的形状导向水热设计用于抗菌和抗癌应用

Elvan Hasanoğlu Özkan¹, Nurdan Kurnaz Yetim², Hamit E Kızıl³

¹Department of Chemistry, Faculty of Science, Gazi University, Teknikokullar, 06500, Ankara, Türkiye, gazi.edu.tr.

Bioinorganic chemistry and applications

|February 25, 2026

概括

新的氧化纳米颗粒 (ZnO-NPs) 显示出强大的抗微生物和抗癌作用. 它们的有效性与独特的花样形态和高表面积有关,为新疗法提供了潜力.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

抗生素耐药细菌对全球健康构成重大威胁.
金属氧化物纳米材料,特别是氧化物纳米颗粒 (ZnO-NPs),显示出对抗微生物和抗癌应用的希望.

研究的目的:

通过水热方法利用不同的表面活性剂合成和描述新的ZnO-NP.
评估合成的 ZnO-NP 的抗微生物和抗癌活性.
调查物理化学性质和生物疗效之间的相关性.

主要方法:

用不同的表面活性剂合成六种ZnO-NP的热水合成.
使用BET,FT-IR,SEM-EDX,XRD和XPS进行表征.
针对细菌和真菌菌株的抗微生物检测.
对H460肺癌细胞的细胞毒性测定.

主要成果:

所有合成的ZnO-NP都表现出显著的抗菌和抗真菌活性.
具有花样形态和高表面积的ZnO-6显示出最高的抗微生物疗效 (25.5毫米的抑制区对抗S. epidermidis).
ZnO-6显示出对H460细胞最强的抗癌潜力,IC50为31.9μg/mL.

结论:

物理化学性质,特别是形态和表面积,直接影响ZnO-NPs的抗微生物和抗癌疗效.
类似花的形态和ZnO-6的高表面积可能会增强ROS生成和细胞膜相互作用,推动其强大的生物活动.
控制ZnO-NP的设计为开发新型抗微生物和抗癌剂提供了显著的潜力.

关键词:

在ZnO-NPs中,抗微生物活性的抗微生物活性.抗微生物耐药性抗微生物耐药性热水制法是一种热水制法.病原性微生物的病原性微生物

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