在健康婴儿中呈阳性便隐性血液检测的高率:一个嵌套的病例控制研究

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Arsal Khan¹, Aaron Jaynes¹, Fatema Ali²

¹Food Allergy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Journal of translational gastroenterology

|February 25, 2026

概括

瓜亚克便隐性血液测试 (gFOBT) 在高达11%的健康婴儿中可能呈阳性,这表明在早期婴儿期诊断食物蛋白诱导过敏性肠道炎 (FPIAP) 的结果时要谨慎.

科学领域:

儿科胃肠病学儿科胃肠病学
过敏免疫学免疫学
诊断测试诊断测试诊断测试

背景情况:

瓜雅便隐性血液测试 (gFOBT) 常用于评估婴儿的食物蛋白诱导过敏性口腔炎 (FPIAP).
早期婴儿期gFOBT对FPIAP诊断的验证率和阳性率尚未得到充分确立.

研究的目的:

评估健康无症状婴儿的gFOBT阳性率,与被诊断患有FPIAP的婴儿相比.
评估gFOBT解释的可靠性,并将结果与定量便免疫化学测试 (FIT) 进行比较.

主要方法:

一项嵌套病例控制研究分析了两天到五个月的婴儿的冷便样本.
瓜亚克便隐性血液测试 (gFOBT) 由三名失明的工作人员进行并解释.
用量化便免疫化学测试 (FIT) 检测血红蛋白用于比较.

主要成果:

8%的健康婴儿 (高达11%,包括模两可的结果) 测试gFOBT阳性.
在被诊断患有FPIAP的婴儿中,74%的婴儿测试gFOBT阳性.
对于gFOBT解释的interrater可靠性为81%;50%的阳性健康样本和29%的阳性FPIAP样本也是FIT阳性.

结论:

瓜亚克便隐性血液测试 (gFOBT) 的阳性发生在高达11%的健康婴儿中.
在幼儿中解释gFOBT结果需要在诊断环境中谨慎.
可能需要进一步的研究来确定使用gFOBT的FPIAP的最终诊断标准.

关键词:

过敏性大肠炎的发生.牛奶蛋白质过敏牛奶蛋白质过敏瓜亚克 (Guaiac) 瓜亚克 (Guaiac) 是一个地区.婴儿婴儿婴儿婴儿婴儿婴儿隐秘血液测试测试隐藏的血液.

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