基因rs7975232多态与乌克兰人口良性增殖性乳腺疾病之间的联系
Olha Obukhova1, Mykola Kyrychenko2, Ivan Lukavenko2
1Department of Physiology and Pathophysiology With Medical Biology Course, Medical Institute of the Sumy State University, Sumy, Ukraine, sumdu.edu.ua.
BioMed research international
|February 25, 2026
概括
维生素D受体 (VDR) 基因多态 rs7975232 与乌克兰女性良性乳腺疾病有关. 年龄会影响与这种VDR基因变异相关的风险.
科学领域:
- 遗传学和分子生物学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 良性乳腺疾病 (BBD) 影响着很大一部分女性.
- 遗传因素,包括维生素D受体 (VDR) 基因变异,都与BBD的发展有关.
- VDR基因多态 rs7975232 已被研究其在各种疾病中的潜在作用.
研究的目的:
- 调查VDR基因多态 rs7975232与乌克兰人口中良性乳腺疾病 (BBD) 发生率之间的关联.
- 探索潜在的改变因素,如年龄,BMI和荷尔蒙状况,对这种关联.
主要方法:
- 进行了一项病例控制研究,其中包括来自乌克兰的106名BBD患者和221名对照.
- 用PCR-RFLP进行了VDR基因rs7975232多态的基因定型.
- 使用SPSS软件进行了统计分析.
主要成果:
- 观察到VDR rs7975232多态和BBD风险之间存在显著的关联,受家族病史,雌醇水平和吸烟等因素的影响.
- 在40岁以下的女性中,异构卵子的BBD风险较高 (p=0.04),在BMI调整 (p=0.16) 后不显著.
- 在40岁及以上的女性中,异构体的BBD风险较低 (p=0.036),在BMI调整后 (p=0.012) 仍然显著. 与主要等位基载体相比,衰退性同位基具有更高的风险 (p=0.033).
结论:
- 在乌克兰人群中,VDR基因rs7975232多态可能作为良性增殖性乳腺疾病的遗传标记.
- 年龄是一个重要的因素,它改变了与BBD中这种VDR基因多态性相关的风险.
- 需要进一步的研究来阐明这种关联背后的确切机制.
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