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吸烟和Clostridioides difficile在40岁或以上的成年人中的殖民化:来自社区肠道微生物群研究的结果

Hong-Ming Chen^1,2, Te-Wei Yang³, Wen-Chien Ko^3,4

¹Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Infection and drug resistance

|February 25, 2026

概括

烟草吸烟与无症状的Clostridioides difficile在台湾的殖民化有关. 这种社区获得的疾病显示出明显的肠道微生物群概况,突出显示生活方式对病原体储存库的影响.

科学领域:

微生物学微生物学
流行病学流行病学
胃肠病学胃肠病学

背景情况:

无症状的Clostridioides difficile殖民 (CdC) 作为传播和潜在的临床感染的储备.
关于CdC风险因素,特别是生活方式和肠道微生物群的社区数据在台湾有限.
本研究调查了台湾社区获得的CdC流行率和风险因素.

研究的目的:

确定南市40岁以上成人社区获得性CdC的患病率.
在社区环境中确定与生活方式相关的CdC风险因素.
探索殖民和非殖民个体之间的肠道微生物组成的差异.

主要方法:

对来自社区卫生查的250个残留便样本进行横截面研究.
使用聚合酶链反应向三酸异合酶 (tpi) 基因的CdC检测.
16S rRNA基因测序用于比较性肠道微生物群分析.

主要成果:

这种CdC的患病率为11.6% (29/250).
吸烟是唯一与CdC相关的独立风险因素 (aOR为2.35,P=0.038).
肠道微生物群分析显示,CdC样本中蛋白质细菌的相对丰度增加.

结论:

在台湾南部,吸烟与社区获得CdC的可能性增加有关.
在CdC个体中,独特的肠道微生物群概况表明吸烟,微生物群变化和殖民易感性之间存在联系.
可修改的生活方式因素与社区CdC流行病学有关,需要进一步研究.

关键词:

克洛斯特里迪奥伊德 (Clostridioides) 困难的殖民化台湾台湾台湾台湾社区社区社区社区社区社区社区社区社区我们的肠道微生物群.吸烟是为了吸烟.

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