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Updated: Feb 26, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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针对蛋白质降解的同介质溶酶向抗体的输送

Dingdong Yuan1, Yishu Bao1, Zhiyi Xu1

  • 1Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 25, 2026
PubMed
概括

研究人员开发了溶酶组分类合酶 (LSP-Coa),其向与癌症相关的蛋白质 (CAPs) 进行降解. 这种由Coacervate介导的色素向蛋白降解 (CoaLPD) 策略对新的癌症治疗有希望.

关键词:
细胞内输送是细胞内输送.lysosome-targeting 的交付方式是:类协同化物 协同化物阶段分离的阶段分离.有针对性的蛋白质降解降解.

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