Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

CDIN1-Codanin-1 complex defective in congenital dyserythropoietic anaemia type I is an RNA nuclease.

Nature communications·2026
Same author

Inhibition of MLLT1 Limits Growth of KMT2A::AFF1 Leukemias Without Killing Healthy Hematopoietic Stem Cells.

Experimental hematology·2026
Same author

ABHD2 activity is not required for the non-genomic action of progesterone on human sperm.

Human reproduction (Oxford, England)·2026
Same author

Pleural fluid neutrophil extracellular traps are associated with disease severity and risk of one-year mortality in pleural infection. An observational, international, multicohort study (TORPIDS-3).

The European respiratory journal·2026
Same author

Development of SYK NanoBRET cellular target engagement assays for gain-of-function variants.

Frontiers in chemical biology·2026
Same author

KDM3A catalyses the oxidation of acetyl-lysine to hydroxyacetyl-lysine on histone H3K9.

Nature chemistry·2026

相关实验视频

Updated: Feb 26, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
09:26

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

Published on: October 15, 2013

14.5K

评估模块42在体外对免疫功能的Aβ独立影响.

Ishita Ajith1,2, Souvika Bakshi1, Emma Mead1,3

  • 1Centre for Medicines Discovery, Oxford, UK.

Alzheimer's & dementia : the journal of the Alzheimer's Association
|February 25, 2026
PubMed
概括

模块42 (M42) 蛋白与阿尔茨海默病 (AD) 相关,影响免疫细胞功能. 米德基因 (MDK) 和TMEFF2ectodomain改变了细胞和信号传递,这表明它在阿米洛伊德病理之外的AD免疫力中发挥了作用.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.在M42蛋白质中.免疫功能 免疫功能 免疫功能一个母体组的母体组.

更多相关视频

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.7K
In Vitro Cellular Activity Evaluation of the Nanoemulsion Vaccine Adjuvant Ophiopogonin D
08:15

In Vitro Cellular Activity Evaluation of the Nanoemulsion Vaccine Adjuvant Ophiopogonin D

Published on: December 9, 2022

2.3K

相关实验视频

Last Updated: Feb 26, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
09:26

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

Published on: October 15, 2013

14.5K
An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.7K
In Vitro Cellular Activity Evaluation of the Nanoemulsion Vaccine Adjuvant Ophiopogonin D
08:15

In Vitro Cellular Activity Evaluation of the Nanoemulsion Vaccine Adjuvant Ophiopogonin D

Published on: December 9, 2022

2.3K

科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 蛋白质组学是指蛋白质组学.

背景情况:

  • 一个新的蛋白质网络,Module 42 (M42),在死后人类大脑中被发现,与阿尔茨海默病 (AD) 病理学有很强的相关性.
  • M42由32种跨膜和细胞外矩阵蛋白组成,包括粉样蛋白前体蛋白 (APP) 和粉样蛋白E (apoE),涉及粉样β (Aβ) 病理.

研究的目的:

  • 在体外系统地评估M42蛋白对免疫细胞功能的Aβ独立作用.
  • 研究M42成分在调节与AD相关的免疫反应中的特定作用.

主要方法:

  • 再组合的M42蛋白被表达和净化.
  • 人类诱导的多能干细胞衍生的巨细胞被用M42蛋白质治疗.
  • 试验评估了细胞形成,细胞内 (Ca2+) 信号传递和细胞活力.

主要成果:

  • 中基因 (MDK) 降低了细胞形成,而具有EGF类和两个follistatin类域2 (TMEFF2) 的跨膜蛋白的ectodomain增加了它.
  • 无论是MDK还是TMEFF2ectodomain都促进了细胞内Ca2+信号传递.
  • TMEFF2 ectodomain抑制了Syk激酶活性;没有M42蛋白影响细胞活力.

结论:

  • M42蛋白质在调节免疫功能方面发挥作用,独立于Aβ病理.
  • 这些发现表明,M42通过调节免疫反应,有助于AD病原体.