生物和机械比较蛋衍生的酸,氧化和矿物三氧化聚合物
Makbule Buse Dundar Sari1, Ayse Demiral2, Mustafa Gungormus3
1Department of Pediatric Dentistry, School of Dentistry, Çanakkale Onsekiz Mart University, Çanakkale, Türkiye.
概括
蛋衍生的酸 (ESDHA) 和矿物三氧化物聚合物 (MTA) 与氧化 (CH) 不同,没有细胞毒性. 埃斯达是一个有前途的,生物相容的替代品,需要机械增强.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料科学 牙科材料科学
- 恢复性牙科 恢复性牙科
背景情况:
- 矿物三氧化聚合物 (MTA) 和氧化 (CH) 在牙科内广泛使用.
- 需要具有生物相容性和成本效益的牙科材料.
- 牙髓干细胞 (HDPSC) 对于牙髓修复和再生至关重要.
研究的目的:
- 为了比较蛋衍生的酸 (ESDHA) 与MTA和CH的机械性能和细胞毒性.
- 评估ESDHA作为牙科生物材料的潜力.
- 评估这些材料与人类牙纸干细胞 (HDPSC) 的相互作用.
主要方法:
- 使用HDPSCs通过实时细胞分析对材料提取物的细胞毒性评估.
- 在不同时间点测量压力强度.
- 使用X射线衍光度,拉曼光谱,SEM和EDS进行结构和化学表征.
主要成果:
- 埃斯达和MTA对HDPSCs没有表现出细胞毒性作用.
- 在第一天,CH表现出初始细胞毒性,其翻倍时间为42.32±1.69小时.
- 在28天内,MTA的压力强度最高 (85.6 ± 3.2 MPa),其次是ESDHA (18.9 ± 1.4 MPa) 和CH (5.1 ± 0.4 MPa).
结论:
- 埃斯达表现出良好的细胞相容性,使其成为一种潜在的替代生物材料.
- 为了更广泛的临床应用,ESDHA要求提高机械性能.
- 在机械强度方面,MTA仍然优越,而CH显示出显著的细胞毒性问题.
更多相关视频
14:55Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
Published on: June 24, 2018
9.8K
07:14Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
Published on: July 27, 2022
4.2K
相关概念视频
01:31Essential Minerals for Bone Health
6.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
6.8K
01:18The Bone Matrix
6.1K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
6.1K
01:24Hydration of Cement
1.0K
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
1.0K